TNT are cellular processes that enable cell-to-cell communication at distances from 30 to 500 µm. The kiloton and megaton of TNT have traditionally been used to describe the energy output, and hence the destructive power, of a nuclear weapon. The 'megaton (of TNT)' is a unit of energy equal to 4.184 petajoules (4.184 × 10 15 J). Several groups have suggested that TNT, cytonemes, and tumor microtubes are different structures, but without specific markers or detailed characteristics, these claims are unsupported and require further research 1. The 'kiloton (of TNT)' is a unit of energy equal to 4.184 terajoules (4.184 × 10 12 J). To re-set the AK240 to play PCM files, I needed to re-open Audirvana Plus, play a PCM file, and then close Audirvana. Normally, TNT formation and associated intercellular communication participate in key biological processes, including development, signaling, and the immune response, but TNT formation during healthy conditions is minimal 1, 2, 3, 4, 5, 6, 7, 8. After playing a DSD file in Audirvana Plus and then closing the program and opening another playback app, such as iTunes or Amarra Symphony, I would only hear high-frequency noise, not music, when I tried to play a PCM file. We and others demonstrated that TNT formation participates in the pathogenesis of several diseases, including HIV 9, 10, 11, 12, 13. However, the role of TNT or tumor microtubes in glioblastoma (GBM) have only recently been explored 14, 15, 16, 17, 18, 19, 20, 21, 22, 23.ĭespite the aggressive treatment, the 2-year survival for GBM patients remains only in the 10–25% range, with few patients surviving beyond 5 years 24, 25.
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